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Tummy or duodenal ulcer. In case you have a belly ulcer or duodenal ulcer, prednisone could enable it to be worse. Having prednisone with an NSAID (ache reliever) for example ibuprofen could also improve your risk of building or worsening an ulcer. For those who have one of those ulcers, talk with your doctor about no matter if prednisone is right